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Form 4 reporting owner · CIK 0001271411

GRAY MICHAEL

CFO and COO

10Open-market trades
3Tickers
+5.28%Avg 90d after buys
+13.0%Avg 90d after sales
−27.5%Avg 180d after buys
+25.4%Avg 180d after sales

UPB price and prints

Upstream Bio, Inc. 3 open-market prints by this insider, 3/16/20269/16/2026. Triangles mark only their Form 4 purchases and sales. Full UPB chart

UPB adjusted close▲ buy▼ sale
5.316.607.909.1910.492026-09-16 sell GRAY MICHAEL2026-06-16 sell GRAY MICHAEL2026-03-16 sell GRAY MICHAEL2026-02-232026-09-18

UPB trades

Clear
DateForm 4TickerSideSharesValue90d180d
9/16/2026
UPBUpstream Bio, IncCFO and COO
Upstream Bio, Inc · Pharmaceutical PreparationsIndustryPharmaceutical PreparationsMkt cap (est.)$764.79MPrice$5.3452w high$32.6052w low$5.31
SELL853$4.7K+12.1%hist+18.8%hist
6/16/2026
UPBUpstream Bio, IncCFO and COO
Upstream Bio, Inc · Pharmaceutical PreparationsIndustryPharmaceutical PreparationsMkt cap (est.)$764.79MPrice$5.3452w high$32.6052w low$5.31
SELL853$5.2K+1.86%+18.8%hist
3/16/2026
UPBUpstream Bio, IncCFO and COO
Upstream Bio, Inc · Pharmaceutical PreparationsIndustryPharmaceutical PreparationsMkt cap (est.)$764.79MPrice$5.3452w high$32.6052w low$5.31
SELL852$7.9K+36.5%+39.5%

Chart uses split-adjusted closes from the first print through the latest available bar. Returns use the last close on or before the trade date and the first close on or after 90 and 180 calendar days. Sales are signed so a declining price is a positive result for the seller. Not investment advice.